US FDA approves Idorsia’s once-daily TRYVIO (aprocitentan) – the first and
only endothelin receptor antagonist for the treatment of high blood pressure
not adequately controlled in combination with other antihypertensives
Ad hoc announcement pursuant to Art. 53 LR TRYVIO™ (aprocitentan) is indicated
for the treatment of hypertension in combination with other antihypertensive
drugs, to lower blood pressure in adult patients who are not adequately
controlled on other drugs. TRYVIO is the first oral anti-hypertensive therapy
which works via a new therapeutic pathway to be approved in almost 40 years.
Idorsia plans to make TRYVIO available to the millions of patients in the US
who are not controlled on other drugs in the second half of 2024. Idorsia to
host an investor webcast to discuss the approval today, March 20, at 15:00hrs
CET.
Allschwil, Switzerland – March 20, 2024
Idorsia Ltd (SIX: IDIA) announced today that the US Food and Drug
Administration (FDA) has approved TRYVIO™ (aprocitentan) for the treatment of
hypertension in combination with other antihypertensive drugs, to lower blood
pressure in adult patients who are not adequately controlled on other drugs. 1
Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular
events, primarily strokes and myocardial infarctions. 1 The recommended dosage
of TRYVIO is 12.5 mg orally once daily, with or without food. 1
Jean-Paul Clozel, MD and Chief Executive Officer of Idorsia commented:
“Today, there are millions of Americans whose blood pressure is not
well-controlled despite existing therapies. This is a major public health issue
leading to a high incidence of cardio- and cerebrovascular events. In order to
help address this issue, Idorsia developed aprocitentan, an endothelin receptor
antagonist suited to the treatment of these patients. Idorsia conducted an
ambitious clinical program in patients remaining hypertensive despite a minimum
of three drugs at their optimal dose and sometimes up to four, five, or even
six antihypertensives. I’m very proud of the Idorsia team and very happy that
physicians will have a new treatment option to treat patients whose blood
pressure is not controlled.”
TRYVIO (aprocitentan) is an endothelin receptor antagonist that inhibits the
binding of endothelin (ET)-1 to ET A and ET B receptors. 1,2 The effects of
ET-1 bear many similarities with the pathophysiology of hypertension, 3 and
ET-1 is a major driver of aldosterone production. 4 Until the approval of
TRYVIO, no systemic antihypertensive medications targeted the ET pathway, 5 as
approved antihypertensive therapies focus on the regulation of salt and water
(diuretics), antagonism of the renin–angiotensin–aldosterone (RAAS) system,
reduction of influx of extracellular calcium into the cell (calcium channel
blockers), sympatholytic activity (beta blockers, central alpha-agonist
agents), or non-selective vasodilatory effects. 6 , 7
TRYVIO was evaluated as a monotherapy in a Phase 2 study in patients with
hypertension, 8 and as an add-on therapy in a Phase 3 study called PRECISION in
patients with confirmed resistant hypertension. 9 In PRECISION, aprocitentan
was well tolerated and superior to placebo in lowering blood pressure at week
4, with a sustained effect at week 40. 10
Martine Clozel, MD and Chief Scientific Officer of Idorsia, commented:
“Early on, we realized that endothelin was involved in patients with
hypertension, especially in those remaining uncontrolled despite other
anti-hypertensive drugs. Since the endothelin pathway was not yet tackled in
these patients, we selected aprocitentan, an endothelin receptor antagonist
with the ideal properties for use in this condition. We were delighted when we
saw the safety and efficacy data with TRYVIO, even on top of multiple
antihypertensives, in patients whose hypertension is not adequately controlled.
The recognition of its potential with today’s FDA approval is great news for
prescribers and patients.”
Michael A. Weber, MD, Professor of Medicine, Division of Cardiovascular
Medicine State University of New York, and an investigator in the PRECISION
study commented:
“Today, we are not able to reduce blood pressure below recommended levels in
at least 10% of the hypertensive patients we treat. As well, it is often
patients at high risk of adverse cardiovascular outcomes and typically with
comorbidities who pose this challenge. We have had to wait for over 30 years to
see the approval of an oral anti-hypertensive agent that works on a new
therapeutic pathway, so TRYVIO provides transformational progress in the field
of systemic hypertension. It is taken as a single daily oral dose that works in
combination with whatever other drugs are being prescribed and without
drug-drug interactions in patients with the burden of uncontrolled
hypertension. TRYVIO is easy for physicians to prescribe and easy for patients
to use.”
Phase 3 clinical study 1, 9 ,10
The efficacy of TRYVIO (aprocitentan) was evaluated in a multipart, Phase 3
multicenter study (PRECISION, NCT03541174) in adults with systolic blood
pressure (SBP) ≥140 mmHg who were prescribed at least three antihypertensive
medications. The trial included a placebo run-in period, which was followed by
three parts as described below. Prior to the placebo run-in period, all
patients were switched to standard background antihypertensive therapy
consisting of an angiotensin receptor blocker, a calcium channel blocker, and a
diuretic, which was continued throughout the study. Patients with concomitant
use of beta-blockers continued this treatment throughout the study.
Following the 4-week placebo run-in period, 730 patients were randomized
equally to aprocitentan at either 12.5 mg, 25 mg, or placebo once daily during
the initial 4-week double-blind (DB) treatment period (part 1). At the end of 4
weeks, all patients entered the single-blind treatment period (part 2) where
they received 25 mg aprocitentan once daily for 32 weeks. At the end of the
32 weeks, patients were re-randomized to receive either 25 mg aprocitentan or
placebo, once daily, during a 12-week DB-withdrawal period (part 3).
The primary efficacy endpoint was the change in sitting SBP (SiSBP) from
baseline to Week 4 during part 1, measured at trough by unattended automated
office blood pressure (uAOBP).
The key secondary endpoint was the change in SiSBP measured at trough by uAOBP
from Week 36 (i.e., prior to randomized withdrawal to 25 mg aprocitentan or
placebo in part 3) to Week 40.
Patients had a mean age of 62 years (range 24 to 84 years) and 60% were male.
Patients were White (83%), African American (11%) or Asian (5%). Approximately
10% were Hispanic. The mean body mass index (BMI) was 34 kg/m 2 (range 18 to
64 kg/m 2 ). At baseline, 19% of patients had an eGFR 30–59 mL/min/1.73 m 2 and
3% had an eGFR 15–29 mL/min/1.73 m 2 . At baseline, 24% of patients had a urine
albumin-to-creatinine ratio (UACR) of 30–300 mg/g and 13% had a UACR >300 mg/g.
Approximately 54% of patients had a medical history of diabetes mellitus, 31%
ischemic heart disease, and 20% congestive heart failure. At baseline, 63% of
patients reported taking four or more antihypertensive medications.
TRYVIO 12.5 mg was statistically superior to placebo in reducing SiSBP at
Week 4 (part 1). The treatment effect was consistent for sitting diastolic BP
(SiDBP).
The persistence of the BP-lowering effect of TRYVIO was demonstrated in part 3
of the trial, in which patients on aprocitentan were re-randomized to placebo
or 25 mg aprocitentan following a period during which all patients were treated
with 25 mg. In patients re-randomized to placebo, the mean SiSBP increased,
whereas in patients re-randomized to 25 mg aprocitentan the mean effect on
SiSBP was maintained and was statistically superior to placebo at Week 40. The
treatment effect was consistent for SiDBP.
Most of the BP-lowering effect occurred within the first two weeks of
treatment with TRYVIO. TRYVIO is not approved for use at a 25 mg dose. The
efficacy for the 25 mg aprocitentan dose as measured in the primary end point
of change in sitting SBP (SiSBP) from baseline to Week 4 in part 1, was similar
to the 12.5 mg dose and thus aprocitentan 12.5 mg is the approved dose.
TRYVIO’s BP-lowering effect appeared consistent among subgroups defined by
age, sex, race, BMI, baseline eGFR, baseline UACR, medical history of diabetes,
and between BP measurement methodologies (uAOBP and ambulatory BP
measurements).
The most frequently reported adverse reactions to TRYVIO during the 4-week
double-blind placebo-controlled treatment period (part 1) of the PRECISION
study were edema/fluid retention and anemia. During the initial 4-week
double-blind placebo-controlled treatment period (part 1), 0.8% of patients
experienced an adverse reaction of hypersensitivity (i.e., rash, erythema,
allergic edema) on TRYVIO compared to no reports in patients treated with
placebo. One patient experienced allergic dermatitis requiring hospitalization
while receiving aprocitentan 25 mg. TRYVIO is contraindicated in patients who
are hypersensitive to aprocitentan or any of its excipients. Use of TRYVIO is
contraindicated in pregnancy.
Lowering BP reduces the risk of fatal and non-fatal cardiovascular events,
primarily strokes and myocardial infarctions. These benefits have been seen in
controlled trials of antihypertensive drugs from a wide variety of
pharmacologic classes. There are no controlled trials demonstrating reduction
of risk of these events with TRYVIO.
Alberto Gimona, MD and Head of Global Clinical Development of Idorsia,
commented:
“When designing PRECISION, we did not shy away from including patients who are
most at risk of the serious negative consequences of hypertension. In addition,
while all patients needed to be on three antihypertensives to join the study,
63 percent of patients were on four or more anti-hypertensives. The study was
therefore truly reflective of the real-world patient population whose blood
pressure is not adequately controlled on other drugs. TRYVIO demonstrated a
clear and consistent effect across all endpoints of blood pressure measurement
and in key sub-populations. As a result, TRYVIO brings hope as a novel,
effective and well-tolerated treatment option for patients with hypertension
not adequately controlled.”
Tosh Butt, President and General Manager of Idorsia US commented:
“The approval of TRYVIO in the US marks another major milestone for Idorsia.
With TRYVIO, we've got an innovative medicine with a unique mode of action in
systemic hypertension. The team at Idorsia has a deep understanding and rich
history in the field of endothelin receptor antagonism. We are eager to provide
physicians and patients with a novel medicine working in a new pathway in
uncontrolled hypertension that can provide additional blood pressure control.
We recognize that the resources required to reach the entire prescribing
community could be substantial, so we will carefully craft the TRYVIO launch
strategy in the coming months, while preparing to make TRYVIO available during
the second half of 2024.”
The team at Idorsia has been working on the research and development of
endothelin receptor antagonists for more than 30 years, successfully bringing
three other molecules from this class to patients in different indications.
ET-1, via its receptors (ET A and ET B ), mediates a variety of deleterious
effects such as vasoconstriction, fibrosis, cell proliferation, and
inflammation. In hypertension, ET-1 can cause endothelial dysfunction, vascular
hypertrophy and remodeling, sympathetic activation, and increased aldosterone
synthesis. 1
Martine Clozel, MD and Chief Scientific Officer of Idorsia, concluded:
“After more than 30 years working in the field of endothelin science, our
research has brought about changes in the treatment paradigm of several
cardiovascular diseases. Now we are bringing significant medical progress for
patients with systemic hypertension. I am convinced that with the data we have
seen, the approval of TRYVIO heralds a new era of endothelin research beyond
hypertension, where we intend to investigate the utility of aprocitentan for
first-in-class applications in new indications.”
TRYVIO REMS
TRYVIO is available only through a restricted program under a REMS called the
TRYVIO REMS because of the risk of embryo-fetal toxicity. Prescribers must be
certified with the TRYVIO REMS by enrolling and completing training. Pharmacies
that dispense TRYVIO must be certified with the TRYVIO REMS.
Important Safety Information
TRYVIO may cause serious side effects, including:
TRYVIO can cause major birth defects if used by pregnant patients and has a
BOXED Warning for embryo-fetal toxicity. People who can become pregnant must
not be pregnant when they start taking TRYVIO or become pregnant during
treatment with TRYVIO or for 1 month after stopping treatment with TRYVIO.
People who can become pregnant should have a negative pregnancy test before
starting treatment with TRYVIO, each month during treatment with TRYVIO, and 1
month after stopping TRYVIO. People who can become pregnant should use
acceptable birth control before starting treatment with TRYVIO, during
treatment with TRYVIO, and for 1 month after stopping TRYVIO because the
medicine may still be in your body.
People can only receive TRYVIO through a restricted program called the TRYVIO
REMS. If you are a person who can become pregnant, your healthcare provider
will talk to you about pregnancy testing recommendations and the need to use
acceptable birth control, the benefits and risks of TRYVIO, and the need to
report suspected pregnancy right away to your healthcare provider.
What is TRYVIO?
TRYVIO is a prescription medicine used to treat high blood pressure
(hypertension) in adults who are taking other high blood pressure medicines and
whose blood pressure is not well controlled.
Do not take TRYVIO if you are pregnant or currently trying to become pregnant.
allergic to aprocitentan or any of the ingredients in TRYVIO.
Before taking TRYVIO, tell your healthcare provider about all of your medical
conditions, including if you: have liver problems have heart failure have
anemia have kidney problems or get dialysis are pregnant or plan to become
pregnant during treatment with TRYVIO. TRYVIO can cause serious birth defects.
are breastfeeding or plan to breastfeed. It is not known if TRYVIO passes into
your breastmilk. Do not breastfeed if you take TRYVIO.
Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
TRYVIO may cause other serious side effects, including: Liver problems .
TRYVIO may cause liver problems. Your healthcare provider should do blood tests
to check your liver before starting treatment and as needed during treatment
with TRYVIO. Tell your healthcare provider if you have any of the following
symptoms of liver problems during treatment with TRYVIO: nausea or vomiting
yellowing of your skin or whites of your eyes pain in the upper right stomach
dark urine tiredness fever loss of appetite itching Fluid retention . Fluid
retention and swelling are common during treatment with TRYVIO and can be
serious. Tell your healthcare provider right away if you have any unusual
weight gain, trouble breathing, or swelling of your ankles or legs. Your
healthcare provider may treat you with other medicines (diuretics) if you
develop fluid retention or swelling. Low red blood cell levels (anemia). Anemia
is common during treatment with TRYVIO and can be serious. Your healthcare
provider will do blood tests to check your red blood cells before starting and
as needed during treatment with TRYVIO. Decreased sperm count. TRYVIO may cause
decreased sperm counts in males and may affect the ability to father a child.
Tell your healthcare provider if being able to have children is important to
you.
Your healthcare provider may stop treatment with TRYVIO if you develop certain
side effects. Tell your healthcare provider if you have any side effect that
bothers you or that does not go away.
These are not all the possible side effects of TRYVIO. Call your doctor for
medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
For more information see the Full Prescribing Information including BOXED
Warning ( PI and Medication Guide ).
Notes to the editor
About Dr Michael A. Weber, MD
Dr. Weber is Professor of Medicine at the SUNY Downstate College of Medicine
in Brooklyn, New York. He received his medical degree from Sydney University in
Australia.
His career has been focused primarily on hypertension and preventive
cardiology. He has published numerous research articles in the medical
literature and has authored or edited 16 books. Together with Dr. Suzanne
Oparil, he is responsible for the widely used reference volume, Hypertension.
Dr. Weber is the Editor-in-Chief of The Journal of Clinical Hypertension. Dr.
Weber was one of the founders of The American Society of Hypertension and has
served as its President. He also served as Chair of the ASH Hypertension
Specialists Program. He is a Fellow of The American College of Physicians, The
American College of Cardiology and The American Heart Association. He has
served on the Cardiovascular and Renal Drugs Advisory Board of the Food and
Drug Administration, and continues as a consultant to that Agency. He has also
served for ten years as Chairman of the Formulary Committee of a major pharmacy
benefits provider serving many of the leading health plans in the United
States.
His main current research interests are in clinical trials of patients at high
risk of cardiovascular events or strokes. He is also participating actively in
trials in patients with metabolic disorders such as diabetes and kidney
disease. Dr. Weber currently serves on the Steering Committees of several
national and international clinical outcomes trials. Dr. Weber serves as a
consultant to Idorsia.
References TRYVIO™ Prescribing Information. Idorsia Pharmaceuticals US Inc.
March/2024 Trensz F, et al. Pharmacological characterization of aprocitentan, a
dual endothelin receptor antagonist, alone and in combination with blockers of
the renin angiotensin system, in two models of experimental hypertension. J
Pharmacol Exp Ther. 2019 Mar; 368(3):462-473. Iglarz M, et al. At the heart of
tissue: endothelin system and end-organ damage. Clin Sci 2010; 119:453-63.
Rossi GP, et al. Endothelin-1 stimulates steroid secretion of human
adrenocortical cells ex vivo via both ETA and ETB receptor subtypes. J Clin
Endocrinol Metab. 1997, 82: 3445-3449 Clozel M. Aprocitentan and the endothelin
system in resistant hypertension. Can J Physiol Pharmacol 2022; 100:573-83.
Whelton P.K., et al. 2018. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/
ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and
management of high blood pressure in adults: a report of the American College
of Cardiology/American Heart Association Task Force on clinical practice
guidelines. Hypertension, 71: e13–e115. Williams B, et al. 2018 ESC/ESH
guidelines for the management of arterial hypertension. Eur Heart J 2018; 39:
3021–104. Verweij P. et al. Randomized Dose-Response Study of the New Dual
Endothelin Receptor Antagonist Aprocitentan in Hypertension. Hypertension.
2020;75:956–965 Danaietash P et al. Identifying and treating resistant
hypertension in PRECISION: A randomized long-term clinical trial with
aprocitentan. J Clin Hypertension 2022 Jul;24(7):804-813. Schlaich MP, et al. A
randomized controlled trial of the dual endothelin antagonist aprocitentan for
resistant hypertension. The Lancet, 2022; Dec 3;400(10367):1927-1937.
Investor webcast
An investor conference call and webcast will be held to discuss the TRYVIO FDA
approval. The call will start with presentations by senior management, followed
by a Q&A session.
Date: Wednesday, March 20, 2024
Time: 15:00 CET | 14:00 GMT | 10:00 ET
Dial-in procedure: Participants are required to register in advance of the
conference (link already open for registration) using the link provided below.
Upon registration, each participant will be provided with participant dial in
numbers, and a unique personal PIN. In the 10 minutes prior to the call start
time, participants will need to use the conference access information provided
in the e-mail received at the point of registering. Participants may also use
the Call Me feature instead of dialing the nearest dial in number.
Online Registration: LINK
Webcast participants should visit Idorsia's website www.idorsia.com 10-15
minutes before the webcast is due to start.
About Idorsia US
Idorsia US, an affiliate of Idorsia, is reaching out for more – we have more
ideas, we see more opportunities, and we want to help more patients. To achieve
this, we will help develop Idorsia into a leading biopharmaceutical company,
with a strong scientific core. With commercial operations based outside of
Philadelphia, PA, one of densest communities of life sciences talent in the
world, we are helping to realize the company’s ambition of bringing innovative
medicines from bench to bedside. Our goal is to build a commercial footprint
that will deliver Idorsia’s deep pipeline of products from its R&D engine to
the US market – with the potential to change the lives of many patients.
About Idorsia
Idorsia Ltd is reaching out for more – We have more ideas, we see more
opportunities and we want to help more patients. In order to achieve this, we
will develop Idorsia into a leading biopharmaceutical company, with a strong
scientific core.
Headquartered near Basel, Switzerland – a European biotech-hub – Idorsia is
specialized in the discovery, development and commercialization of small
molecules to transform the horizon of therapeutic options. Idorsia has a
20-year heritage of drug discovery, a broad portfolio of innovative drugs in
the pipeline, an experienced team of professionals covering all disciplines
from bench to bedside, and commercial operations in Europe and North America –
the ideal constellation for bringing innovative medicines to patients.
Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June
2017 and has over 800 highly qualified specialists dedicated to realizing our
ambitious targets.
For further information, please contact
US media
Kyle Stout
Ketchum
Kyle.stout@ketchum.com
973-216-9505
Global Investors & Media
Andrew C. Weiss
Senior Vice President, Head of Investor Relations & Corporate Communications
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
+41 58 844 10 10
investor.relations@idorsia.com • media.relations@idorsia.com • www.idorsia.com
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'are expected to', 'will', 'will continue', 'should', 'would be', 'seeks',
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company's investment and research and development programs and anticipated
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prove incorrect, actual results may vary materially from those described herein
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Anhang Medienmitteilung PDF